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CAAS sequences Gnathostoma spinigerum Mitochondrial Genome

DATE:2015-08-27       SOURCE:Chinese Academy of Agricultural Sciences, MOA

Dr. Zhu Xingquan with Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences and his research team on livestock parasitic diseases, for the first time in the world, sequenced Gnathostoma spinigerum Mitochondrial Genome recently. It is believed that their findings will lay a foundation for future studies on molecular epidemiology, population genetics and systematics of G. spinigerum


The academic journal Scientific Reports published the major findings.


In spite of the significance as pathogens, G.spinigerumas remain poorly understood at the molecular level. Dr. Zhu Xingquan and his team applied Sanger methodology in their study and found that the ring-shaped mt genome of G. spinigerum was 14,079bp in size, and presented a different gene arrangement pattern from the other 29 patterns seen in nematodes revealed by previous researches. 

They analyzed 12 protein-coding genes of G. spinigerum mt genome, and provided insights into the phylogenetic relationships among several major lineages of nematodes, showing that G.spinigerum was most closely related to Cucullanus robustu.


This study was supported by the University of the Sunshine Coast of Australia, Zhongshan Entry-Exit Inspection & Quarantine Bureau and the First Affiliated Hospital of Sun Yat-sen University. The study was funded by national S&T international cooperation programs and innovation programs of Gansu and CAAS.


In cooperation with the University of Melbourne of Australia and Shenzhen based BGI, Lanzhou Veterinary Research Institute also used next-generation sequencing to produce a draft genome and transcriptome of Toxocara canis, providing a useful resource for future studies on parasites, as well as new interventions against related nematodiases.


The academic journal Nature Communications reported their study on Toxocara canis in February.


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